3-tert-butoxycarbonyl-7-chloro-6-dimethylaminocarbonylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine → HCID 66706524, compound

HRID 911475Notes

Reaction equation

HRID 911475 reaction equation
C(OC([N:8]1[CH2:14][CH2:13][C:12]2[C:15]([S:20]C(=O)N(C)C)=[C:16]([Cl:19])[CH:17]=[CH:18][C:11]=2[CH2:10][CH2:9]1)=O)(C)(C)C.CS(O[CH:31]([C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][N:37]=1)[C:32]([F:35])([F:34])[F:33])(=O)=O>>[ClH:19].[Cl:19][C:16]1[CH:17]=[CH:18][C:11]2[CH2:10][CH2:9][NH:8][CH2:14][CH2:13][C:12]=2[C:15]=1[S:20][CH:31]([C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][N:37]=1)[C:32]([F:33])([F:34])[F:35]

Participants

3

Reactant 2

HCID 576559793-tert-butoxycarbonyl-7-chloro-6-dimethylaminocarbonylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepineHCID 58074002HCID 58074002, compound

Product 1

HCID 66706524HCID 66706524, compound

Procedure

Use a method similar to the Preparation 177 to react 3-tert-butoxycarbonyl-7-chloro-6-dimethylcarbamoylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine with (±)-2-[1-methanesulfonyloxy-(2,2,2-trifluoroethyl)]-pyridine. Use a method similar to the General Procedure 1-5, basic workup, and a method similar to the General Procedure 2-2 to give the title compound as a white solid. MS (APCI+) m/z: 373 (M+H)+.

Workup

  1. customsimilar to the Preparation 177

Sources & evidence

ORD record
ord-2b255388837f4a9dabc2c2a7c3b1eb08
Source dataset
uspto-grants-2011_09
Patent number
US08022062B2

Reaction notes

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