3-tert-butoxycarbonyl-7-chloro-6-dimethylaminocarbonylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine → HCID 86629657, compound

HRID 911487Notes

Reaction equation

HRID 911487 reaction equation
C(OC([N:8]1[CH2:14][CH2:13][C:12]2[C:15]([S:20][C:21](=O)N(C)C)=[C:16]([Cl:19])[CH:17]=[CH:18][C:11]=2[CH2:10][CH2:9]1)=O)(C)(C)C.Cl.BrC[C:29]1[CH:34]=[CH:33][CH:32]=[C:31]([Cl:35])[N:30]=1>>[ClH:19].[Cl:19][C:16]1[CH:17]=[CH:18][C:11]2[CH2:10][CH2:9][NH:8][CH2:14][CH2:13][C:12]=2[C:15]=1[S:20][CH2:21][C:29]1[CH:34]=[CH:33][CH:32]=[C:31]([Cl:35])[N:30]=1

Participants

3

Reactant 2

HCID 576559793-tert-butoxycarbonyl-7-chloro-6-dimethylaminocarbonylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepineHCID 86629658HCID 86629658, compound

Product 1

HCID 86629657HCID 86629657, compound

Procedure

Use a method similar to the Preparation 177, using 3-tert-butoxycarbonyl-7-chloro-6-dimethylcarbamoylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine and 2-bromomethyl-6-chloropyridine hydrochloride to give, after deprotection by a method similar to the General Procedure 1-4, the title compound as an off-white solid. MS (APCI+) m/z: 339 (M+H)+.

Workup

  1. customsimilar to the Preparation 177
  2. customto give

Sources & evidence

ORD record
ord-ea489ca79b2d44ec8f272c32d5b4aa3c
Source dataset
uspto-grants-2011_09
Patent number
US08022062B2

Reaction notes

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