2-(Chloromethyl)-3-methoxypyridine → HCID 66706914, compound

HRID 911488Notes

Reaction equation

HRID 911488 reaction equation
C(OC([N:8]1[CH2:14][CH2:13][C:12]2[C:15]([S:20][C:21](=O)N(C)C)=[C:16]([Cl:19])[CH:17]=[CH:18][C:11]=2[CH2:10][CH2:9]1)=O)(C)(C)C.ClC[C:28]1[C:33]([O:34][CH3:35])=[CH:32][CH:31]=[CH:30][N:29]=1>>[ClH:19].[Cl:19][C:16]1[CH:17]=[CH:18][C:11]2[CH2:10][CH2:9][NH:8][CH2:14][CH2:13][C:12]=2[C:15]=1[S:20][CH2:21][C:28]1[C:33]([O:34][CH3:35])=[CH:32][CH:31]=[CH:30][N:29]=1

Participants

3

Reactant 2

HCID 146587112-(Chloromethyl)-3-methoxypyridineHCID 576559793-tert-butoxycarbonyl-7-chloro-6-dimethylaminocarbonylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Product 1

HCID 66706914HCID 66706914, compound

Procedure

Use a method similar to the Example 315, using 3-tert-butoxycarbonyl-7-chloro-6-dimethylcarbamoylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine and 2-chloromethyl-3-methoxypyridine to give, after deprotection by a method similar to the General Procedure 1-4, the title compound as a white solid (71 mg). MS (APCI+) m/z: 335 (M+H)+.

Workup

  1. customto give

Sources & evidence

ORD record
ord-61c89aca070d422bbec9f20c338a5f99
Source dataset
uspto-grants-2011_09
Patent number
US08022062B2

Reaction notes

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