3-tert-butoxycarbonyl-7-chloro-6-dimethylaminocarbonylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine → HCID 66707375, compound

HRID 911490Notes

Reaction equation

HRID 911490 reaction equation
C(OC([N:8]1[CH2:14][CH2:13][C:12]2[C:15]([S:20][C:21](=O)N(C)C)=[C:16]([Cl:19])[CH:17]=[CH:18][C:11]=2[CH2:10][CH2:9]1)=O)(C)(C)C.Cl.[CH2:27]([C:31]1[CH:32]=[CH:33][C:34](CCl)=[N:35][CH:36]=1)[CH2:28][CH2:29][CH3:30]>>[ClH:19].[CH2:27]([C:31]1[CH:32]=[CH:33][C:34]([CH2:21][S:20][C:15]2[C:12]3[CH2:13][CH2:14][NH:8][CH2:9][CH2:10][C:11]=3[CH:18]=[CH:17][C:16]=2[Cl:19])=[N:35][CH:36]=1)[CH2:28][CH2:29][CH3:30]

Participants

3

Reactant 2

HCID 576559793-tert-butoxycarbonyl-7-chloro-6-dimethylaminocarbonylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepineHCID 66706974HCID 66706974, compound

Product 1

HCID 66707375HCID 66707375, compound

Procedure

Use a method similar to the Example 315, using 3-tert-butoxycarbonyl-7-chloro-6-dimethylcarbamoylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine and 5-butyl-2-chloromethylpyridine hydrochloride to give the title compound as a white solid. MS (APCI+) m/z: 330 (M+H)+.

Sources & evidence

ORD record
ord-8e3d146aa18148b4a587b391f84e7d6b
Source dataset
uspto-grants-2011_09
Patent number
US08022062B2

Reaction notes

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