1-(Bromomethyl)-2-(trifluoromethyl)benzene → HCID 66707316, compound

HRID 911506Notes

Reaction equation

HRID 911506 reaction equation
C(OC([N:8]1[CH2:14][CH2:13][C:12]2[C:15]([S:20][C:21](=O)N(C)C)=[C:16]([Cl:19])[CH:17]=[CH:18][C:11]=2[CH2:10][CH2:9]1)=O)(C)(C)C.[F:26][C:27]([F:37])([F:36])[C:28]1[CH:35]=[CH:34][CH:33]=[CH:32][C:29]=1CBr>>[ClH:19].[Cl:19][C:16]1[CH:17]=[CH:18][C:11]2[CH2:10][CH2:9][NH:8][CH2:14][CH2:13][C:12]=2[C:15]=1[S:20][CH2:21][C:29]1[CH:32]=[CH:33][CH:34]=[CH:35][C:28]=1[C:27]([F:37])([F:36])[F:26]

Participants

3

Reactant 2

HCID 1230571-(Bromomethyl)-2-(trifluoromethyl)benzeneHCID 576559793-tert-butoxycarbonyl-7-chloro-6-dimethylaminocarbonylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Product 1

HCID 66707316HCID 66707316, compound

Procedure

Use a method similar to the Example 347 to react 3-tert-butoxycarbonyl-7-chloro-6-dimethylcarbamoylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine with 2-trifluoromethylbenzyl bromide. Use a method similar to the General Procedure 1-4 to give the title compound as a waxy tan solid. MS (APCI+) m/z: 372 (M+H)+.

Sources & evidence

ORD record
ord-c01cc32f34f64fa9840661192750692b
Source dataset
uspto-grants-2011_09
Patent number
US08022062B2

Reaction notes

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