Methyl 3-(bromomethyl)benzoate → HCID 66706952, compound

HRID 911508Notes

Reaction equation

HRID 911508 reaction equation
C(OC([N:8]1[CH2:14][CH2:13][C:12]2[C:15]([S:20][C:21](=O)N(C)C)=[C:16]([Cl:19])[CH:17]=[CH:18][C:11]=2[CH2:10][CH2:9]1)=O)(C)(C)C.BrC[C:28]1[CH:29]=[C:30]([CH:35]=[CH:36][CH:37]=1)[C:31]([O:33][CH3:34])=[O:32]>>[ClH:19].[Cl:19][C:16]1[CH:17]=[CH:18][C:11]2[CH2:10][CH2:9][NH:8][CH2:14][CH2:13][C:12]=2[C:15]=1[S:20][CH2:21][C:28]1[CH:37]=[CH:36][CH:35]=[C:30]([C:31]([O:33][CH3:34])=[O:32])[CH:29]=1

Participants

3

Reactant 2

HCID 517981Methyl 3-(bromomethyl)benzoateHCID 576559793-tert-butoxycarbonyl-7-chloro-6-dimethylaminocarbonylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Product 1

HCID 66706952HCID 66706952, compound

Procedure

Use a method similar to the Example 347 to react 3-tert-butoxycarbonyl-7-chloro-6-dimethylcarbamoylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine with methyl 3-(bromomethyl)benzoate. Use a method similar to the General Procedure 1-5, basic workup, and a method similar to the General Procedure 2-2 to give the title compound. MS (APCI+) m/z: 362 (M+H)+.

Sources & evidence

ORD record
ord-122ac004821f46138fe79603da5dd99f
Source dataset
uspto-grants-2011_09
Patent number
US08022062B2

Reaction notes

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