Cycloheptanol → 7-Chloro-6-(4-cycloheptyloxybenzylthio)-2,3,4,5-tetrahydro-1H-benzo[d]azepine Hydrochloride

HRID 911522Notes

Reaction equation

HRID 911522 reaction equation
[C:1]([O:4][C:5]1[CH:31]=[CH:30][C:8]([CH2:9][S:10][C:11]2[C:21]3[CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16][C:15]=3[CH:14]=[CH:13][C:12]=2[Cl:29])=[CH:7][CH:6]=1)(=O)[CH3:2].[CH:32]1(O)[CH2:38][CH2:37]CC[CH2:34][CH2:33]1>>[ClH:29].[Cl:29][C:12]1[CH:13]=[CH:14][C:15]2[CH2:16][CH2:17][NH:18][CH2:19][CH2:20][C:21]=2[C:11]=1[S:10][CH2:9][C:8]1[CH:30]=[CH:31][C:5]([O:4][CH:1]2[CH2:2][CH2:37][CH2:38][CH2:32][CH2:33][CH2:34]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 10399CycloheptanolHCID 576560566-(4-acetoxybenzylthio)-3-tert-butoxycarbonyl-7-chloro-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Product 1

HCID 667067887-Chloro-6-(4-cycloheptyloxybenzylthio)-2,3,4,5-tetrahydro-1H-benzo[d]azepine Hydrochloride

Procedure

Use a method similar to the Example 423 to react 6-(4-acetoxybenzylthio)-3-tert-butoxycarbonyl-7-chloro-2,3,4,5-tetrahydro-1H-benzo[d]azepine with cycloheptanol. Use a method similar to the General Procedure 1-4 to give the title compound as a white solid. MS (ES+) m/z: 416 (M+H)+.

Sources & evidence

ORD record
ord-f119681c2a2447788fd30f75c94d4e34
Source dataset
uspto-grants-2011_09
Patent number
US08022062B2

Reaction notes

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