Furan, 2-(bromomethyl)tetrahydro- → HCID 66706715, compound

HRID 911546Notes

Reaction equation

HRID 911546 reaction equation
C(OC([N:8]1[CH2:14][CH2:13][C:12]2[C:15]([S:20][C:21](=O)N(C)C)=[C:16]([Cl:19])[CH:17]=[CH:18][C:11]=2[CH2:10][CH2:9]1)=O)(C)(C)C.BrC[CH:28]1[CH2:32][CH2:31][CH2:30][O:29]1>>[ClH:19].[Cl:19][C:16]1[CH:17]=[CH:18][C:11]2[CH2:10][CH2:9][NH:8][CH2:14][CH2:13][C:12]=2[C:15]=1[S:20][CH2:21][CH:28]1[CH2:32][CH2:31][CH2:30][O:29]1

Participants

3

Reactant 2

HCID 14501Furan, 2-(bromomethyl)tetrahydro-HCID 576559793-tert-butoxycarbonyl-7-chloro-6-dimethylaminocarbonylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Product 1

HCID 66706715HCID 66706715, compound

Procedure

Use a method similar to the Example 330, using 3-tert-butoxycarbonyl-7-chloro-6-dimethylcarbamoylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine and 2-(bromomethyl)tetrahydrofuran to give, after deprotection by the General Procedure 1-4, the title compound as white crystals. MS (APCI+) m/z: 298 (M+H)+.

Workup

  1. customto give

Sources & evidence

ORD record
ord-6ca0c79a7f2a438ba8c49b135e730f0a
Source dataset
uspto-grants-2011_09
Patent number
US08022062B2

Reaction notes

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