2-(Bromomethyl)tetrahydro-2H-pyran → HCID 66706598, compound

HRID 911547Notes

Reaction equation

HRID 911547 reaction equation
C(OC([N:8]1[CH2:14][CH2:13][C:12]2[C:15]([S:20][C:21](=O)N(C)C)=[C:16]([Cl:19])[CH:17]=[CH:18][C:11]=2[CH2:10][CH2:9]1)=O)(C)(C)C.BrC[CH:28]1[CH2:33][CH2:32][CH2:31][CH2:30][O:29]1>>[ClH:19].[Cl:19][C:16]1[CH:17]=[CH:18][C:11]2[CH2:10][CH2:9][NH:8][CH2:14][CH2:13][C:12]=2[C:15]=1[S:20][CH2:21][CH:28]1[CH2:33][CH2:32][CH2:31][CH2:30][O:29]1

Participants

3

Reactant 2

HCID 1419172-(Bromomethyl)tetrahydro-2H-pyranHCID 576559793-tert-butoxycarbonyl-7-chloro-6-dimethylaminocarbonylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Product 1

HCID 66706598HCID 66706598, compound

Procedure

Use a method similar to the Example 330, using 3-tert-butoxycarbonyl-7-chloro-6-dimethylcarbamoylthio-2,3,4,5-tetrahydro-1H-benzo[d]azepine and 2-(bromomethyl)tetrahydropyran to give, after deprotection by the General Procedure 1-4, the title compound as a white solid. MS (APCI+) m/z: 312 (M+H)+.

Workup

  1. customto give

Sources & evidence

ORD record
ord-42c6fd2fc4824ab7945a3c8d6c40c116
Source dataset
uspto-grants-2011_09
Patent number
US08022062B2

Reaction notes

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