Hydrazine → HCID 57656177, compound

Participants

Reaction Conditions

Reaction Steps

Suspend 3-tert-butoxycarbonyl-7-chloro-6-[3-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-propylthio]-2,3,4,5-tetrahydro-1H-benzo[d]azepine (1.20 g, 2.39 mmol) in ethanol (53.2 mL), add hydrazine (0.150 mL, 4.78 mmol) and heat at 65° C. for 2 h. Cool to ambient temperature, filter from precipitate, and concentrate in vacuo to provide the 6-(3-aminopropylthio)-3-tert-butoxycarbonyl-7-chloro-2,3,4,5-tetrahydro-1H-benzo[d]azepine (861 mg, 97%). MS (APCI+) m/z: 371 (M+H)+.

Provenance & Evidence