(2-Bromoethoxy)-tert-butyldimethylsilane → HCID 67382106, compound

HRID 911558Notes

Reaction equation

HRID 911558 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:14][CH2:13][C:12]2[C:15]([S:23]C(=O)N(C)C)=[C:16]([C:19]([F:22])([F:21])[F:20])[CH:17]=[CH:18][C:11]=2[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].Br[CH2:30][CH2:31][O:32][Si:33]([C:36]([CH3:39])([CH3:38])[CH3:37])([CH3:35])[CH3:34]>>[C:1]([O:5][C:6]([N:8]1[CH2:14][CH2:13][C:12]2[C:15]([S:23][CH2:30][CH2:31][O:32][Si:33]([C:36]([CH3:39])([CH3:38])[CH3:37])([CH3:35])[CH3:34])=[C:16]([C:19]([F:20])([F:22])[F:21])[CH:17]=[CH:18][C:11]=2[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 3608067(2-Bromoethoxy)-tert-butyldimethylsilaneHCID 57656392HCID 57656392, compound

Product 1

HCID 67382106HCID 67382106, compound

Procedure

Use a method similar to the Preparation 177, using 3-tert-butoxycarbonyl-6-dimethylcarbamoylthio-7-trifluoromethyl-2,3,4,5-tetrahydro-benzo[d]azepine and (2-bromoethoxy)-tert-butyldimethylsilane to give the desired intermediate.

Workup

  1. customsimilar to the Preparation 177

Sources & evidence

ORD record
ord-f0292b619f544a639b998ccca1ca22c8
Source dataset
uspto-grants-2011_09
Patent number
US08022062B2

Reaction notes

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