HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromothiophene → 2-[(Trimethylsilyl)ethynyl]thiophene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromothiophene | HCID 13851 | — |
| Reactant | Trimethylsilylacetylene | HCID 66111 | — |
| Product | 2-[(Trimethylsilyl)ethynyl]thiophene | HCID 596870 | 81% |
Reaction Steps
Use a method similar to the General Procedure 8 to couple 2-bromo-thiophene (0.97 nm, 10 mmol) with ethynyl-trimethylsilane (2.82 mL, 20 mmol). Purify by chromatography on silica gel eluting with isohexane to give the desired intermediate (1.46 g, 81%). GC-MS m/z 180 (M+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08022062B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-93017a89bd9b4668b40f9cbd73af4b99 |
| Source note | uspto-grants-2011_09 |