反应详情

Add slowly tert-butylacetyl chloride (2 g, 14.858 mmol) to an ice-cold stirred solution of aluminum trichloride (2.972 g, 22.28 mmol) in anhydrous toluene (40 mL). Stir the reaction mixture at ambient temperature overnight. Add slowly ice-cold water and extract the mixture twice with EtOAc. Dry the combined organic extracts over Na2SO4, filter and concentrate in vacuo to give the desired intermediate (2.82 g, 100%) that was used without any further purification. GC-MS m/z: 190 (M+).

1. additionAdd slowly ice-cold water
2. extractionextract the mixture twice with EtOAc
3. dry with materialDry the combined organic extracts over Na2SO4
4. filtrationfilter
5. concentrationconcentrate in vacuo