참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | N-bromobutanimide | HCID 67184 | — |
| 반응물 | 4-Bromo-3-chlorotoluene | HCID 138789 | — |
| 촉매 | Benzoyl Peroxide | HCID 7187 | — |
| 용매 | Carbon Tetrachloride | HCID 5943 | — |
| 생성물 | 1-Bromo-4-(bromomethyl)-2-chlorobenzene | HCID 12947392 | 85.4% |
반응 단계
Add NBS (5.266 g, 23.9 mmol) and benzoyl peroxide (49 mg, 0.2 mmol) to a solution of 4-bromo-3-chlorotoluene (4.925 g, 23.9 mmol) in carbon tetrachloride (49 mL) and heat overnight at 90° C. Cool to 0° C. and filter the mixture. Concentrate the filtrate in vacuo to obtain the desired intermediate as a yellow oil (5.807 g, 85%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08022062B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_09 |
|---|
| ORD ID | ord-a3a893bd5e9c4ab48735f2fb1be93928 |
|---|
| 출처 메모 | uspto-grants-2011_09 |
|---|
