HCID 57656146, compound → HCID 57656316, compound

Participants

Reaction Conditions

Reaction Steps

Add manganese dioxide (7.276 g, 83.7 mmol) to a solution of N-(tert-butoxycarbonyl)-2-chloro-4-(1-hydroxy-3,3-dimethyl-butyl)-benzylamine (1.819 g, 5.3 mmol) in anhydrous 1,4-dioxane (75 mL) at room temperature. Heat the mixture at 70° C. overnight. Filter the reaction mixture over Celite® and concentrate in vacuo. Purify by chromatography on silica gel eluting with hexane/EtOAc (85:15) to obtain the desired intermediate as a yellow oil (1.362 g, 76%).

Provenance & Evidence