HCID 67382347, compound → HCID 57656622, compound

Participants

Reaction Conditions

Reaction Steps

Add manganese dioxide (472 mg, 5.429 mmol) to a solution of 5-tert-butoxycarbonylaminomethyl-2-(1-hydroxy-3,3-diethyl-butyl)-pyridine (118 mg, 0.383 mmol) in anhydrous 1,4-dioxane (5 mL) at room temperature. Heat the reaction mixture at 70° C. overnight. Filter the reaction mixture over Celite® and concentrate in vacuo to obtain the desired intermediate (104 mg, 89%).

Provenance & Evidence