Hydrochloric Acid → HCID 178526130, compound

Participants

Reaction Steps

Add methyl 4-cycloheptylthio-benzoate (1.1 g, 4.16 mmol) and sodium hydroxide (500 mg, 12.5 mmol) to methanol (20 mL) and stir overnight. Add 2M aqueous HCl (20 mL) and extract the aqueous phase with dichloromethane. Wash the combined organic extracts with water (20 mL) and brine (20 mL). Dry the organic solution over Na2SO4, filter and concentrate in vacuo to provide the desired intermediate as a white solid (984 mg, 94%). MS (APCI) m/z: 251 (M+H)+.

Provenance & Evidence