HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 1-(2-Chloroethyl)pyrrolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1-(2-Hydroxyethyl)-2-pyrrolidinone | HCID 76980 | — |
| Product | 1-(2-Chloroethyl)pyrrolidin-2-one | HCID 3156650 | — |
Reaction Steps
Add thionyl chloride (5 mL) to 1-(2-hydroxy-ethyl)-pyrrolidin-2-one (1.12 mL, 10.0 mmol) dropwise then stir at room temperature for 10 min. Remove solvent in vacuo to give the title compound as an orange oil. MS (ES+) m/z: 148 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08022062B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-72cf470a6663417a8733faed9d9dd273 |
| Source note | uspto-grants-2011_09 |