Succinic Acid → 7-Chloro-6-[3-(3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-propylthio]-2,3,4,5-tetrahydro-1H-benzo[d]azepine Succinate

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Reaction Steps

Dissolve 7-chloro-6-[3-(3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-propylthio]-2,3,4,5-tetrahydro-1H-benzo[d]azepine (101 mg, 0.24 mmol) in a mixture of diethyl ether (3 mL) and methanol (2 mL). Add succinic acid (28.7 mg, 0.24 mmol) and allow the resultant suspension to stir at ambient temperature for 2 h. Concentrate in vacuo and dry the residue in a vacuum oven to afford the title compound as a white solid. MS (ES+) m/z: 415 (M+H)+.

Provenance & Evidence