Hydrochloric Acid → HCID 19385224, compound

Participants

Reaction Conditions

Reaction Steps

A concentrated hydrochloric acid solution (120 mL) was added to a suspension of 4-amino-3-nitrobenzene trifluoride (20.06 g) and ethanol (400 mL) in air. The mixture was heated to 80° C. with stirring. After reduced iron (27.09 g) was gradually added thereto over a period of 15 minutes, the mixture was heated to reflux for 1 hour with stirring. After the mixture was cooled on ice, the resulting solution was neutralized with aqueous ammonium hydroxide and then extracted with dichloromethane. The extract was washed with water, concentrated, and purified by silica-gel column chromatography to yield 3,4-diaminobenzene trifluoride (12.495 g).

Provenance & Evidence