1-Bromo-4-phenylbutan-2-one → N-(5-Bromo-3-phenoxypyridin-2-yl)-4-phenethylthiazol-2-amine

HRID 911805Notes

Reaction equation

HRID 911805 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([O:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:5]([NH:8][C:9]([NH2:11])=[S:10])=[N:6][CH:7]=1.Br[CH2:20][C:21](=O)[CH2:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[Br:1][C:2]1[CH:3]=[C:4]([O:12][C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:5]([NH:8][C:9]2[S:10][CH:20]=[C:21]([CH2:22][CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[N:11]=2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 126080271-Bromo-4-phenylbutan-2-oneHCID 866314811-(5-Bromo-3-phenoxypyridin-2-yl)thiourea

Product 1

HCID 57742623N-(5-Bromo-3-phenoxypyridin-2-yl)-4-phenethylthiazol-2-amine

Procedure

Prepared according to the method of Example 7 Step E from 1-(5-bromo-3-phenoxypyridin-2-yl)thiourea and 1-bromo-4-phenylbutan-2-one. 1H NMR (d6-DMSO) δ 8.26 (m, 1H), 7.45 (m, 3H), 7.31-7.11 (m, 8H), 6.74 (s, 1H), 2.92 (m, 4H). Mass spectrum (apci) m/z 452.3 (M+H).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-ea9c0126c542418a94b4209854c462f8
Source dataset
uspto-grants-2011_09
Patent number
US08022223B2

Reaction notes

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