HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → 5-(Benzyloxy)-3-bromopyridin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | 5-Benzyloxy-pyridin-2-ylamine hydrochloride | HCID 66995170 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 5-(Benzyloxy)-3-bromopyridin-2-amine | HCID 58209073 | 17% |
Reaction Steps
5-(Benzyloxy)pyridin-2-amine hydrochloride (52.3 g, 221 mmol) and sodium acetate (45.3 g, 552 mmol) were dissolved in acetic acid (300 mL). Bromine (11.3 mL, 221 mmol) was added slowly and stirred at ambient temperature for 18 hours. After an aqueous workup, the material was purified over silica gel to give the title compound (10.5 g, 17.0% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08022223B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-e777de273f744b17bde59e740081637f |
| Source note | uspto-grants-2011_09 |