2-Chloro-3-isothiocyanatopyridine → N-(3-Phenoxy-5-(pyridin-4-ylthio)pyridin-2-yl)thiazolo[5,4-b]pyridin-2-amine

HRID 911854Notes

Reaction equation

HRID 911854 reaction equation
Cl[C:2]1[C:7]([N:8]=[C:9]=[S:10])=[CH:6][CH:5]=[CH:4][N:3]=1.[O:11]([C:18]1[C:19]([NH2:31])=[N:20][CH:21]=[C:22]([S:24][C:25]2[CH:30]=[CH:29][N:28]=[CH:27][CH:26]=2)[CH:23]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[O:11]([C:18]1[C:19]([NH:31][C:9]2[S:10][C:2]3[C:7]([N:8]=2)=[CH:6][CH:5]=[CH:4][N:3]=3)=[N:20][CH:21]=[C:22]([S:24][C:25]2[CH:30]=[CH:29][N:28]=[CH:27][CH:26]=2)[CH:23]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 128680882-Chloro-3-isothiocyanatopyridineHCID 669954533-Phenoxy-5-(pyridin-4-ylthio)pyridin-2-amine

Product 1

HCID 57742566N-(3-Phenoxy-5-(pyridin-4-ylthio)pyridin-2-yl)thiazolo[5,4-b]pyridin-2-amine

Procedure

Prepared according to the method of Example 292 from 2-chloro-3-isothiocyanatopyridine (0.116 g, 0.677 mmol) and 3-phenoxy-5-(pyridin-4-ylthio)pyridin-2-amine. 1H NMR (d6-DMSO) δ 7.10 (d, 2H), 7.17-7.23 (m, 3H), 7.40-7.47 (m, 4H), 7.97 (bs, 1H), 8.36-8.41 (m, 4H), 11.88 (bs, 1H).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-0a26c93cf16e4c2585e4fc1e3b54becc
Source dataset
uspto-grants-2011_09
Patent number
US08022223B2

Reaction notes

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