HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 911929Generated: October 30, 2026
Formamide → thieno(2,3-d)pyrimidin-4(3H)-one
https://huagongshe.com/reaction/911929
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formamide | HCID 713 | — |
| Reactant | Methyl 2-amino-3-thenoate | HCID 78381 | — |
| Solvent | Water | HCID 962 | — |
| Product | thieno(2,3-d)pyrimidin-4(3H)-one | HCID 2808547 | 23% |
Reaction Steps
Methyl 2-aminothiophene-3-carboxylate (10 g, 64 mmol) was charged with formamide (50 mL). The reaction was heated at 190° C. under nitrogen for 3 hours. The solution was cooled to room temperature. The slurry was poured into 125 mL of water and extracted with chloroform:isopropyl alcohol mixture (2 times). The solution was concentrated and triturated to afford the title compound (2.25 g, 23%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08022223B2 |
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| Source dataset | uspto-grants-2011_09 |
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| ORD ID | ord-38900a185fa6430990b5828a3425df7e |
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| Source note | uspto-grants-2011_09 |
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