Phenyl isocyanate → HCID 57812278, compound

Participants

Reaction Steps

A mixture of 7-[(R)-1-(2,6-Dichloro-3-fluorophenyl)-ethoxy]-3-(1,2,3,6-tetrahydropyridin-4-yl)-furo[3,2-c]pyridin-6-ylamine (10.0 mg, 0.0237 mmol), phenyl isocyanate (0.00519 g, 0.0436 mmol), DIPEA (0.033 mL, 0.19 mmol) in DMF (1 mL) was stirred at rt for 15 min. Purification by HPLC afforded the title compound as a colorless solid. 1H NMR (CD3OD, 400 MHz): δ=1.90 (d, J=6.8 Hz, 3H), 2.58 (br. s., 2H), 3.77 (t, J=5.7 Hz, 2H), 4.25 (d, J=2.5 Hz, 2H), 6.32 (br. s., 1H), 6.52 (d, J=6.8 Hz, 1H), 7.04 (t, J=7.3 Hz, 1H), 7.17-7.32 (m, 3H), 7.34-7.46 (m, 3H) 7.69 (s, 1H), 8.23 (s, 1H). MS (ES+): m/z 541.03/543.05 (100/68) [MH+]. HPLC: tR=3.39 min (ZQ3, polar—5 min).

Provenance & Evidence