Diisopropylethylamine → HCID 57812571, compound

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Reaction Steps

A mixture of 7-[(R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-(1,2,3,6-tetrahydropyridin-4-yl)-furo[3,2-c]pyridin-6-ylamine (10.0 mg, 0.0237 mmol), 2-fluorophenyl isocyanate (0.00597 g, 0.0436 mmol), DIPEA (0.033 mL, 0.19 mmol) in DMF (1 mL) was stirred at rt for 3 h. Purification by HPLC afforded the title compound. 1H NMR (400 MHz, CD3OD): δ=1.89 (d, J=6.8 Hz, 3H), 2.58 (br. s., 2H), 3.69-3.80 (m, 2H), 4.25 (d, J=2.5 Hz, 2H), 6.31 (br. s., 1H), 6.51 (q, J=6.7 Hz, 1H), 7.08-7.16 (m, 3H), 7.22 (t, J=8.7 Hz, 1H), 7.40 (dd, J=9.0, 4.9 Hz, 1H), 7.45-7.52 (m, 1H), 7.68 (s, 1H), 8.22 (s, 1H). MS (ES+): m/z 559.05/561.04 (100/75) [MH+]. HPLC: tR=3.42 min (ZQ3, polar—5 min).

Provenance & Evidence