Ethyl isocyanate → HCID 57812560, compound

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Reaction Steps

A mixture of 7-[(R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-(1,2,3,6-tetrahydro-pyridin-4-yl)furo[3,2-c]pyridin-6-ylamine (10.0 mg, 0.0237 mmol), ethyl isocyanate (0.00310 g, 0.0436 mmol), DIPEA (0.033 mL, 0.19 mmol) in DMF (1 mL) was stirred at rt for 15 min. Purification by HPLC afforded the title compound as a colorless solid. 1H NMR (400 MHz, CD3OD): δ=1.13 (t, J=7.2 Hz, 3H), 1.87 (d, J=6.8 Hz, 3H), 2.48 (br. s., 2H), 3.22 (q, J=7.1 Hz, 2H), 3.62 (t, J=5.8 Hz, 2H), 4.06 (d, J=2.5 Hz, 2H), 6.25 (br. s., 1H), 6.43-6.56 (m, 1H), 7.21 (t, J=8.7 Hz, 1H), 7.39 (dd, J=9.0, 4.9 Hz, 1H), 7.65 (s, 1H), 8.16 (s, 1H). MS (ES+): m/z 493.02/495.04 (100/68) [MH+]. HPLC: tR=2.95 min (ZQ3, polar—5 min).

Provenance & Evidence