1-(3-Bromo-5-fluorophenyl)ethanol → HCID 57812462, compound

HRID 912047Notes

Reaction equation

HRID 912047 reaction equation
[Br:1][C:2]1[CH:9]=[C:8]([Cl:10])[C:5]([CH:6]=[O:7])=[C:4]([Cl:11])[CH:3]=1.[CH3:12][Mg]Br.BrC1C=C(C(O)C)C=C(F)C=1>>[Br:1][C:2]1[CH:3]=[C:4]([Cl:11])[C:5]([CH:6]([OH:7])[CH3:12])=[C:8]([Cl:10])[CH:9]=1

Participants

4

Reactant 3

HCID 222402011-(3-Bromo-5-fluorophenyl)ethanolHCID 566042544-Bromo-2,6-dichlorobenzaldehydeHCID 178418573HCID 178418573, compound

Product 1

HCID 57812462HCID 57812462, compound

Procedure

The title compound was prepared from 4-bromo-2,6-dichlorobenzaldehyde (prepared according to WO 2008/021851) by reaction with methylmagnesium bromide following the procedure for 1-(3-bromo-5-fluorophenyl)ethanol as described.

Sources & evidence

ORD record
ord-ff92634e8f5742bba1d77b0aabd40901
Source dataset
uspto-grants-2011_09
Patent number
US08022206B2

Reaction notes

Loading…