4-[4-Chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]morpholine → HCID 178489899, compound

HRID 912077Notes

Reaction equation

HRID 912077 reaction equation
Cl[C:2]1[C:7]([CH2:8][CH2:9]Cl)=[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[CH:12]=2)[N:5]=[C:4]([N:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)[N:3]=1.[OH:25][C:26]1[CH:31]=[CH:30][C:29]([NH2:32])=[CH:28][N:27]=1>>[CH3:18][O:17][C:13]1[CH:12]=[C:11]([C:6]2[C:7]3[CH2:8][CH2:9][N:32]([C:29]4[CH:30]=[CH:31][C:26]([OH:25])=[N:27][CH:28]=4)[C:2]=3[N:3]=[C:4]([N:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)[N:5]=2)[CH:16]=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 592449884-[4-Chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]morpholineHCID 178507770HCID 178507770, compound

Product 1

HCID 178489899HCID 178489899, compound

Procedure

In the same manner as Example 1-A-01, from 4-[4-chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]-morpholine and 2-hydroxy-pyridin-5-ylamine, the desired compound was obtained.

Sources & evidence

ORD record
ord-9d2a2a0c62414bceb856f226c5507716
Source dataset
uspto-grants-2011_09
Patent number
US08022205B2

Reaction notes

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