1-Methyl-3-aminopyrazole → HCID 24889091, compound

HRID 912084Notes

Reaction equation

HRID 912084 reaction equation
ClC1C(CCCl)=C(C2C=CC=C(OC)C=2)N=C(N2CCOCC2)N=1.CN1C=CC(N)=N1.C[O:33][C:34]1[CH:35]=[C:36]([C:40]2[C:41]3[CH2:54][CH2:53][N:52]([C:55]4[CH:59]=[CH:58][N:57]([CH3:60])[N:56]=4)[C:42]=3[N:43]=[C:44]([N:46]3[CH2:51][CH2:50][O:49][CH2:48][CH2:47]3)[N:45]=2)[CH:37]=[CH:38][CH:39]=1>>[CH3:60][N:57]1[CH:58]=[CH:59][C:55]([N:52]2[C:42]3[N:43]=[C:44]([N:46]4[CH2:47][CH2:48][O:49][CH2:50][CH2:51]4)[N:45]=[C:40]([C:36]4[CH:35]=[C:34]([OH:33])[CH:39]=[CH:38][CH:37]=4)[C:41]=3[CH2:54][CH2:53]2)=[N:56]1

Participants

4

Reactant 3

HCID 1372541-Methyl-3-aminopyrazoleHCID 592449884-[4-Chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]morpholineHCID 67385958HCID 67385958, compound

Product 1

HCID 24889091HCID 24889091, compound

Procedure

In the same manner as Example 1-A-01, from 4-[4-chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]-morpholine and 1-methyl-1H-pyrazol-3-ylamine, 4-(3-methoxy-phenyl)-7-(1-methyl-1H-pyrazol-3-yl)-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine was obtained, and subsequently, further in the same manner as Example 1-A-09, the desired compound was obtained.

Sources & evidence

ORD record
ord-d26b7c60d97d4abdae6d62d104dd4027
Source dataset
uspto-grants-2011_09
Patent number
US08022205B2

Reaction notes

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