3-Aminobenzonitrile → HCID 24889092, compound

HRID 912085Notes

Reaction equation

HRID 912085 reaction equation
ClC1C(CCCl)=C(C2C=CC=C(OC)C=2)N=C(N2CCOCC2)N=1.C(C1C=C(C=CC=1)N)#N.C[O:35][C:36]1[CH:37]=[C:38]([C:42]2[C:43]3[CH2:56][CH2:55][N:54]([C:57]4[CH:58]=[C:59]([CH:62]=[CH:63][CH:64]=4)[C:60]#[N:61])[C:44]=3[N:45]=[C:46]([N:48]3[CH2:53][CH2:52][O:51][CH2:50][CH2:49]3)[N:47]=2)[CH:39]=[CH:40][CH:41]=1>>[OH:35][C:36]1[CH:37]=[C:38]([C:42]2[C:43]3[CH2:56][CH2:55][N:54]([C:57]4[CH:58]=[C:59]([CH:62]=[CH:63][CH:64]=4)[C:60]#[N:61])[C:44]=3[N:45]=[C:46]([N:48]3[CH2:49][CH2:50][O:51][CH2:52][CH2:53]3)[N:47]=2)[CH:39]=[CH:40][CH:41]=1

Participants

4

Reactant 3

HCID 167023-AminobenzonitrileHCID 592449884-[4-Chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]morpholineHCID 67385520HCID 67385520, compound

Product 1

HCID 24889092HCID 24889092, compound

Procedure

In the same manner as Example 1-A-01, from 4-[4-chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]-morpholine and 3-cyanoaniline, 3-[4-(3-methoxy-phenyl)-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl]-benzonitrile was obtained, and subsequently, further in the same manner as Example 1-A-09, the desired compound was obtained.

Sources & evidence

ORD record
ord-d78ea66b37664d0e9e79576344a52b62
Source dataset
uspto-grants-2011_09
Patent number
US08022205B2

Reaction notes

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