4-[4-Chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]morpholine → 3-[7-(3-Dimethylamino-phenyl)-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl]-phenol

HRID 912087Notes

Reaction equation

HRID 912087 reaction equation
ClC1C(CCCl)=C(C2C=CC=C(OC)C=2)N=C(N2CCOCC2)N=1.C[O:26][C:27]1[CH:28]=[C:29]([C:33]2[C:34]3[CH2:47][CH2:46][N:45]([C:48]4[CH:49]=[C:50]([N:54]([CH3:56])[CH3:55])[CH:51]=[CH:52][CH:53]=4)[C:35]=3[N:36]=[C:37]([N:39]3[CH2:44][CH2:43][O:42][CH2:41][CH2:40]3)[N:38]=2)[CH:30]=[CH:31][CH:32]=1>>[CH3:55][N:54]([CH3:56])[C:50]1[CH:49]=[C:48]([N:45]2[C:35]3[N:36]=[C:37]([N:39]4[CH2:40][CH2:41][O:42][CH2:43][CH2:44]4)[N:38]=[C:33]([C:29]4[CH:28]=[C:27]([OH:26])[CH:32]=[CH:31][CH:30]=4)[C:34]=3[CH2:47][CH2:46]2)[CH:53]=[CH:52][CH:51]=1

Participants

3

Reactant 2

HCID 592449884-[4-Chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]morpholineHCID 67387490{3-[4-(3-Methoxy-phenyl)-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-dimethyl-amine

Product 1

HCID 248890943-[7-(3-Dimethylamino-phenyl)-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl]-phenol

Procedure

In the same manner as Example 1-A-01, from 4-[4-chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]-morpholine and 3-N,N-dimethylaminoaniline, {3-[4-(3-methoxy-phenyl)-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl]-phenyl}-dimethyl-amine was obtained, and subsequently, further in the same manner as Example 1-A-09, the desired compound was obtained.

Sources & evidence

ORD record
ord-4da2b1266af546a9bb76a38b95ddeb83
Source dataset
uspto-grants-2011_09
Patent number
US08022205B2

Reaction notes

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