O-Toluidine → HCID 24889261, compound

HRID 912089Notes

Reaction equation

HRID 912089 reaction equation
ClC1C(CCCl)=C(C2C=CC=C(OC)C=2)N=C(N2CCOCC2)N=1.CC1C=CC=CC=1N.C[O:34][C:35]1[CH:36]=[C:37]([C:41]2[C:42]3[CH2:55][CH2:54][N:53]([C:56]4[CH:61]=[CH:60][CH:59]=[CH:58][C:57]=4[CH3:62])[C:43]=3[N:44]=[C:45]([N:47]3[CH2:52][CH2:51][O:50][CH2:49][CH2:48]3)[N:46]=2)[CH:38]=[CH:39][CH:40]=1>>[N:47]1([C:45]2[N:46]=[C:41]([C:37]3[CH:36]=[C:35]([OH:34])[CH:40]=[CH:39][CH:38]=3)[C:42]3[CH2:55][CH2:54][N:53]([C:56]4[CH:61]=[CH:60][CH:59]=[CH:58][C:57]=4[CH3:62])[C:43]=3[N:44]=2)[CH2:52][CH2:51][O:50][CH2:49][CH2:48]1

Participants

4

Reactant 3

HCID 7242O-ToluidineHCID 592449884-[4-Chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]morpholineHCID 67385984HCID 67385984, compound

Product 1

HCID 24889261HCID 24889261, compound

Procedure

In the same manner as Example 1-A-01, from 4-[4-chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]-morpholine and 2-methylaniline, 4-(3-methoxy-phenyl)-2-morpholin-4-yl-7-o-tolyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine was obtained, and subsequently, further in the same manner as Example 1-A-09, the desired compound was obtained.

Sources & evidence

ORD record
ord-37dee0d29afc410aa263e0c95e29cbed
Source dataset
uspto-grants-2011_09
Patent number
US08022205B2

Reaction notes

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