2,4-Dimethylaniline → HCID 24889262, compound

HRID 912090Notes

Reaction equation

HRID 912090 reaction equation
ClC1C(CCCl)=C(C2C=CC=C(OC)C=2)N=C(N2CCOCC2)N=1.CC1C=C(C)C=CC=1N.[CH3:34][C:35]1[CH:40]=[C:39]([CH3:41])[CH:38]=[CH:37][C:36]=1[N:42]1[C:46]2[N:47]=[C:48]([N:59]3[CH2:64][CH2:63][O:62][CH2:61][CH2:60]3)[N:49]=[C:50]([C:51]3[CH:56]=[CH:55][CH:54]=[C:53]([O:57]C)[CH:52]=3)[C:45]=2[CH2:44][CH2:43]1>>[CH3:34][C:35]1[CH:40]=[C:39]([CH3:41])[CH:38]=[CH:37][C:36]=1[N:42]1[C:46]2[N:47]=[C:48]([N:59]3[CH2:60][CH2:61][O:62][CH2:63][CH2:64]3)[N:49]=[C:50]([C:51]3[CH:52]=[C:53]([OH:57])[CH:54]=[CH:55][CH:56]=3)[C:45]=2[CH2:44][CH2:43]1

Participants

4

Reactant 3

HCID 72502,4-DimethylanilineHCID 592449884-[4-Chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]morpholineHCID 67386081HCID 67386081, compound

Product 1

HCID 24889262HCID 24889262, compound

Procedure

In the same manner as Example 1-A-01, from 4-[4-chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]-morpholine and 2,4-dimethylaniline, 7-(2,4-dimethyl-phenyl)-4-(3-methoxy-phenyl)-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine was obtained, and subsequently, further in the same manner as Example 1-A-09, the desired compound was obtained.

Sources & evidence

ORD record
ord-e2bcc11e5e7c495f85b633af2f2984f6
Source dataset
uspto-grants-2011_09
Patent number
US08022205B2

Reaction notes

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