N,N-Dimethyl-1,3-propanediamine → HCID 59244372, compound

HRID 912091Notes

Reaction equation

HRID 912091 reaction equation
ClC1C(CCCl)=C(C2C=CC=C(OC)C=2)N=C(N2CCOCC2)N=1.CN(C)CCCN.C[O:33][C:34]1[CH:35]=[C:36]([C:40]2[C:41]3[CH2:54][CH2:53][N:52]([CH2:55][CH2:56][CH2:57][N:58]([CH3:60])[CH3:59])[C:42]=3[N:43]=[C:44]([N:46]3[CH2:51][CH2:50][O:49][CH2:48][CH2:47]3)[N:45]=2)[CH:37]=[CH:38][CH:39]=1>>[CH3:60][N:58]([CH3:59])[CH2:57][CH2:56][CH2:55][N:52]1[C:42]2[N:43]=[C:44]([N:46]3[CH2:47][CH2:48][O:49][CH2:50][CH2:51]3)[N:45]=[C:40]([C:36]3[CH:35]=[C:34]([OH:33])[CH:39]=[CH:38][CH:37]=3)[C:41]=2[CH2:54][CH2:53]1

Participants

4

Reactant 3

HCID 7993N,N-Dimethyl-1,3-propanediamineHCID 592449884-[4-Chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]morpholineHCID 67385860HCID 67385860, compound

Product 1

HCID 59244372HCID 59244372, compound

Procedure

In the same manner as Example 1-A-01, from 4-[4-chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]-morpholine and N,N-dimethyl-1,3-propanediamine, {3-[4-(3-methoxy-phenyl)-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl]-propyl}-dimethyl-amine was obtained, and subsequently, further in the same manner as Example 1-A-09, the desired compound was obtained.

Sources & evidence

ORD record
ord-2be9a8306b5f49be90cbc2f32ce344a2
Source dataset
uspto-grants-2011_09
Patent number
US08022205B2

Reaction notes

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