2-Aminopyrimidine → HCID 24889437, compound

HRID 912093Notes

Reaction equation

HRID 912093 reaction equation
ClC1C(CCCl)=C(C2C=CC=C(OC)C=2)N=C(N2CCOCC2)N=1.NC1N=CC=CN=1.C[O:33][C:34]1[CH:35]=[C:36]([C:40]2[C:41]3[CH2:54][CH2:53][N:52]([C:55]4[CH:60]=[CH:59][CH:58]=[CH:57][N:56]=4)[C:42]=3[N:43]=[C:44]([N:46]3[CH2:51][CH2:50][O:49][CH2:48][CH2:47]3)[N:45]=2)[CH:37]=[CH:38][CH:39]=1>>[N:46]1([C:44]2[N:45]=[C:40]([C:36]3[CH:35]=[C:34]([OH:33])[CH:39]=[CH:38][CH:37]=3)[C:41]3[CH2:54][CH2:53][N:52]([C:55]4[CH:60]=[CH:59][CH:58]=[CH:57][N:56]=4)[C:42]=3[N:43]=2)[CH2:47][CH2:48][O:49][CH2:50][CH2:51]1

Participants

4

Reactant 3

HCID 79782-AminopyrimidineHCID 592449884-[4-Chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]morpholineHCID 67385519HCID 67385519, compound

Product 1

HCID 24889437HCID 24889437, compound

Procedure

In the same manner as Example 1-A-01, from 4-[4-chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]-morpholine and 2-aminopyrimidine, 4-(3-methoxy-phenyl)-2-morpholin-4-yl-7-pyridin-2-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine was obtained, and subsequently, further in the same manner as Example 1-A-09, the desired compound was obtained.

Sources & evidence

ORD record
ord-f647516eb39e4ef8bee60464ea17dfb9
Source dataset
uspto-grants-2011_09
Patent number
US08022205B2

Reaction notes

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