5-Methylpyrimidin-2-amine → HCID 24889438, compound

HRID 912094Notes

Reaction equation

HRID 912094 reaction equation
ClC1C(CCCl)=C(C2C=CC=C(OC)C=2)N=C(N2CCOCC2)N=1.NC1N=CC(C)=CN=1.C[O:34][C:35]1[CH:36]=[C:37]([C:41]2[C:42]3[CH2:55][CH2:54][N:53]([C:56]4[CH:61]=[CH:60][C:59]([CH3:62])=[CH:58][N:57]=4)[C:43]=3[N:44]=[C:45]([N:47]3[CH2:52][CH2:51][O:50][CH2:49][CH2:48]3)[N:46]=2)[CH:38]=[CH:39][CH:40]=1>>[CH3:62][C:59]1[CH:60]=[CH:61][C:56]([N:53]2[C:43]3[N:44]=[C:45]([N:47]4[CH2:48][CH2:49][O:50][CH2:51][CH2:52]4)[N:46]=[C:41]([C:37]4[CH:36]=[C:35]([OH:34])[CH:40]=[CH:39][CH:38]=4)[C:42]=3[CH2:55][CH2:54]2)=[N:57][CH:58]=1

Participants

4

Reactant 3

HCID 129999335-Methylpyrimidin-2-amineHCID 592449884-[4-Chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]morpholineHCID 67386175HCID 67386175, compound

Product 1

HCID 24889438HCID 24889438, compound

Procedure

In the same manner as Example 1-A-01, from 4-[4-chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]-morpholine and 2-amino-5-methylpyrimidine, 4-(3-methoxy-phenyl)-7-(5-methyl-pyridin-2-yl)-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine was obtained, and subsequently, further in the same manner as Example 1-A-09, the desired compound was obtained.

Sources & evidence

ORD record
ord-1f21c344b4c2411895c0064aa5aa3123
Source dataset
uspto-grants-2011_09
Patent number
US08022205B2

Reaction notes

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