4-(Methylsulfonyl)aniline → HCID 24889766, compound

HRID 912104Notes

Reaction equation

HRID 912104 reaction equation
Cl[C:2]1[C:7]([CH2:8][CH2:9]Cl)=[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:17]C)[CH:12]=2)[N:5]=[C:4]([N:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)[N:3]=1.[CH3:25][S:26]([C:29]1[CH:35]=[CH:34][C:32]([NH2:33])=[CH:31][CH:30]=1)(=[O:28])=[O:27].COC1C=C(C2C3CCN(C4C=CC=C(S(C)(=O)=O)C=4)C=3N=C(N3CCOCC3)N=2)C=CC=1>>[CH3:25][S:26]([C:29]1[CH:35]=[CH:34][C:32]([N:33]2[C:2]3[N:3]=[C:4]([N:19]4[CH2:24][CH2:23][O:22][CH2:21][CH2:20]4)[N:5]=[C:6]([C:11]4[CH:12]=[C:13]([OH:17])[CH:14]=[CH:15][CH:16]=4)[C:7]=3[CH2:8][CH2:9]2)=[CH:31][CH:30]=1)(=[O:27])=[O:28]

Participants

4

Reactant 3

HCID 796174-(Methylsulfonyl)anilineHCID 592449884-[4-Chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]morpholineHCID 67385879HCID 67385879, compound

Product 1

HCID 24889766HCID 24889766, compound

Procedure

In the same manner as Example 1-A-01, from 4-[4-chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]-morpholine and 4-methanesulfonylaniline, 4-(3-methoxy-phenyl)-7-(3-methanesulfonylphenyl)-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine was obtained, and subsequently, further in the same manner as Example 1-A-09, the desired compound was obtained.

Sources & evidence

ORD record
ord-16aba28c243042c7a2dd83f9c4ab3c77
Source dataset
uspto-grants-2011_09
Patent number
US08022205B2

Reaction notes

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