Benzenesulfonamide, 3-amino- → HCID 24889935, compound

HRID 912106Notes

Reaction equation

HRID 912106 reaction equation
ClC1C(CCCl)=C(C2C=CC=C(OC)C=2)N=C(N2CCOCC2)N=1.NC1C=C(S(N)(=O)=O)C=CC=1.C[O:37][C:38]1[CH:39]=[C:40]([C:44]2[C:45]3[CH2:58][CH2:57][N:56]([C:59]4[CH:64]=[CH:63][CH:62]=[C:61]([S:65]([NH2:68])(=[O:67])=[O:66])[CH:60]=4)[C:46]=3[N:47]=[C:48]([N:50]3[CH2:55][CH2:54][O:53][CH2:52][CH2:51]3)[N:49]=2)[CH:41]=[CH:42][CH:43]=1>>[OH:37][C:38]1[CH:39]=[C:40]([C:44]2[C:45]3[CH2:58][CH2:57][N:56]([C:59]4[CH:60]=[C:61]([S:65]([NH2:68])(=[O:67])=[O:66])[CH:62]=[CH:63][CH:64]=4)[C:46]=3[N:47]=[C:48]([N:50]3[CH2:55][CH2:54][O:53][CH2:52][CH2:51]3)[N:49]=2)[CH:41]=[CH:42][CH:43]=1

Participants

4

Reactant 3

HCID 7377Benzenesulfonamide, 3-amino-HCID 592449884-[4-Chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]morpholineHCID 67386408HCID 67386408, compound

Product 1

HCID 24889935HCID 24889935, compound

Procedure

In the same manner as Example 1-A-01, from 4-[4-chloro-5-(2-chloroethyl)-6-(3-methoxyphenyl)-pyrimidin-2-yl]-morpholine and 3-aminobenzene sulfonamide, 4-(3-methoxy-phenyl)-7-(3-aminosulfonylphenyl)-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine was obtained, and subsequently, further in the same manner as Example 1-A-09, the desired compound was obtained.

Sources & evidence

ORD record
ord-f45b9d16ae094473b220fe9344c3de7d
Source dataset
uspto-grants-2011_09
Patent number
US08022205B2

Reaction notes

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