Sodium t-butoxide → HCID 178489900, compound

Participants

Reaction Steps

Morpholinoformamidine bromate salt (200 mg, 0.952 mmol), 3-(3-methoxybenzoyl)dihydropyran-2-one (544 mg, 3.6 mmol) and sodium t-butoxide (230 mg, 2.32 mmol) were added into a microwave reaction tube, and dissolved in t-BuOH (3 ml). After irradiation of microwave (200 W, 120° C.) for 1 hour, the solvent was removed under reduced pressure, to obtain a crude product as a brown solid. This was purified by silica gel column chromatography (dichloromethane/methanol=95/5), to obtain 5-(2-hydroxyethyl)-6-(3-methoxyphenyl)-2-(morpholin-4-yl)-pyrimidin-4-ol and 4-(3-methoxyphenyl)-2-(morpholin-4-yl)-5,6-furo[2,3-d]pyrimidine as colorless solid (Yield 16%).

Provenance & Evidence