Potassium Phosphate, Tribasic → 4-(2,4-Dimethoxy-pyrimidin-5-yl)-2-morpholin-4-yl-7-pyridin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine

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Reaction Conditions

Reaction Steps

To 4-chloro-2-morpholin-4-yl-7-pyridin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine (40 mg, 0.126 mmol), 2,4-dimethoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrimidine (67 mg, 0.252 mmol), palladium acetate (1.4 mg, 0.0063 mmol), S-Phos (5.2 mg, 0.0126 mmol) and potassium phosphate (53.5 mg, 0.252 mmol), dimethylformamide (1 ml) was added, followed by being degassed under ultrasonic irradiation. This was stirred at 100° C. for 12 hours, followed by addition of water, and the resulting solid was filtered, which was washed with ethyl acetate, to obtain the desired compound as a colorless solid (15.7 mg, yield 30%).

Provenance & Evidence