Boronic Acid → HCID 59244970, compound

HRID 912121Notes

Reaction equation

HRID 912121 reaction equation
Cl[C:2]1[C:3]2[CH2:16][CH2:15][N:14]([C:17]3[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=3)[C:4]=2[N:5]=[C:6]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[N:7]=1.[F:23][C:24]1[CH:25]=[C:26](B(O)O)[CH:27]=[CH:28][CH:29]=1.B(O)O>>[F:23][C:24]1[CH:29]=[C:28]([C:2]2[C:3]3[CH2:16][CH2:15][N:14]([C:17]4[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=4)[C:4]=3[N:5]=[C:6]([N:8]3[CH2:13][CH2:12][O:11][CH2:10][CH2:9]3)[N:7]=2)[CH:27]=[CH:26][CH:25]=1

Participants

4

Reactant 3

HCID 61668Boronic AcidHCID 27339863-Fluorophenylboronic acidHCID 592447084-chloro-2-morpholin-4-yl-7-pyridin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine

Product 1

HCID 59244970HCID 59244970, compound

Procedure

In the same manner as Example 1-B-10, using 4-chloro-2-morpholin-4-yl-7-pyridin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine, and 3-fluorophenylboronic acid as a boronic acid, the desired compound was obtained.

Sources & evidence

ORD record
ord-dd1dac226fa34a15a95eeaa1435e3d65
Source dataset
uspto-grants-2011_09
Patent number
US08022205B2

Reaction notes

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