Boronic Acid → 2-Morpholin-4-yl-7-pyridin-4-yl-4-pyrimidin-5-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine

HRID 912123Notes

Reaction equation

HRID 912123 reaction equation
Cl[C:2]1[C:3]2[CH2:16][CH2:15][N:14]([C:17]3[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=3)[C:4]=2[N:5]=[C:6]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[N:7]=1.[N:23]1[CH:28]=[C:27](B(O)O)[CH:26]=[N:25][CH:24]=1.B(O)O>>[N:8]1([C:6]2[N:7]=[C:2]([C:27]3[CH:28]=[N:23][CH:24]=[N:25][CH:26]=3)[C:3]3[CH2:16][CH2:15][N:14]([C:17]4[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=4)[C:4]=3[N:5]=2)[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1

Participants

4

Reactant 3

HCID 61668Boronic AcidHCID 2795193(Pyrimidin-5-yl)boronic acidHCID 592447084-chloro-2-morpholin-4-yl-7-pyridin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine

Product 1

HCID 592442452-Morpholin-4-yl-7-pyridin-4-yl-4-pyrimidin-5-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine

Procedure

In the same manner as Example 1-B-10, using 4-chloro-2-morpholin-4-yl-7-pyridin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine, and pyrimidin-5-boronic acid as a boronic acid, the desired compound was obtained.

Sources & evidence

ORD record
ord-5c34707e562040ab9a172e307af2b446
Source dataset
uspto-grants-2011_09
Patent number
US08022205B2

Reaction notes

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