Boronic Acid → HCID 178420795, compound

HRID 912126Notes

Reaction equation

HRID 912126 reaction equation
Cl[C:2]1[C:3]2[CH2:16][CH2:15][N:14]([C:17]3[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=3)[C:4]=2[N:5]=[C:6]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[N:7]=1.CC1(C)C(C)(C)OB([C:31]2[CH:39]=[CH:38][C:34]3[NH:35][CH:36]=[N:37][C:33]=3[CH:32]=2)O1.B(O)O>>[NH:35]1[C:34]2[CH:38]=[CH:39][C:31]([C:2]3[C:3]4[CH2:16][CH2:15][N:14]([C:17]5[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=5)[C:4]=4[N:5]=[C:6]([N:8]4[CH2:13][CH2:12][O:11][CH2:10][CH2:9]4)[N:7]=3)=[CH:32][C:33]=2[N:37]=[CH:36]1

Participants

4

Reactant 3

HCID 61668Boronic AcidHCID 592450134-Chloro-2-morpholin-4-yl-7-pyridin-3-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidineHCID 178431023HCID 178431023, compound

Product 1

HCID 178420795HCID 178420795, compound

Procedure

In the same manner as Example 1-B-10, using 4-chloro-2-morpholin-4-yl-7-pyridin-3-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine, and 5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-benzimidazole as a boronic acid, the desired compound was obtained.

Sources & evidence

ORD record
ord-922ffe5ffc3942068c0a8515f2041271
Source dataset
uspto-grants-2011_09
Patent number
US08022205B2

Reaction notes

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