Boronic Acid → 4-(3-Benzyloxy-2,6-difluoro-phenyl)-2-morpholin-4-yl-7-pyridin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine

HRID 912129Notes

Reaction equation

HRID 912129 reaction equation
Cl[C:2]1[C:3]2[CH2:16][CH2:15][N:14]([C:17]3[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=3)[C:4]=2[N:5]=[C:6]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[N:7]=1.[CH2:23]([O:30][C:31]1[C:32]([F:41])=[C:33](B(O)O)[C:34]([F:37])=[CH:35][CH:36]=1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.B(O)O>>[CH2:23]([O:30][C:31]1[C:32]([F:41])=[C:33]([C:2]2[C:3]3[CH2:16][CH2:15][N:14]([C:17]4[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=4)[C:4]=3[N:5]=[C:6]([N:8]3[CH2:13][CH2:12][O:11][CH2:10][CH2:9]3)[N:7]=2)[C:34]([F:37])=[CH:35][CH:36]=1)[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Participants

4

Reactant 3

HCID 61668Boronic AcidHCID 162177043-(Benzyloxy)-2,6-difluorobenzeneboronic acidHCID 592447084-chloro-2-morpholin-4-yl-7-pyridin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine

Product 1

HCID 248902744-(3-Benzyloxy-2,6-difluoro-phenyl)-2-morpholin-4-yl-7-pyridin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine

Procedure

In the same manner as Example 1-B-10, using 4-chloro-2-morpholin-4-yl-7-pyridin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine, and 3-benzyloxy-2,6-difluorophenylboronic acid as a boronic acid, the desired compound was obtained.

Sources & evidence

ORD record
ord-21bb019b10f547c1a7908b8e89d5c967
Source dataset
uspto-grants-2011_09
Patent number
US08022205B2

Reaction notes

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