(4-Ethylpiperazin-1-yl)-(4-methyl-3-nitrophenyl)methanone → 5-[(4-Ethylpiperazin-1-YL)carbonyl]-2-methylaniline

Participants

Reaction Steps

(4-Ethyl-piperazin-1-yl)-(4-methyl-3-nitro-phenyl)-methanone (1.06 g, 3.82 mmol) obtained in Step A was stirred for 16 hours in methanol (20 ml) under a hydrogen atmosphere in the presence of 10% palladium carbon. After the reaction mixture was filtered, the filtrate was concentrated under reduced pressure, to obtain (4-ethyl-piperazin-1-yl)-(3-amino-4-methyl-phenyl)-methanone (1.0 g, quant.).

Provenance & Evidence