Hydrochloric Acid → 4-(4-{2-[Bis-(4-methoxy-benzyl)-amino]-pyrimidin-5-yl}-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidine-7-yl)-benzoic acid

Participants

Reaction Conditions

Reaction Steps

A dimethylformamide solution (15 ml) of bis-(4-methoxy-benzyl)-[5-(2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-pyrimidin-2-yl]-amine (700 mg, 1.30 mmol), 4-bromobenzoic acid (313 mg, 1.56 mmol), tris(dibenzylideneacetone) dipalladium (29.7 mg, 0.0324 mmol), X-Phos (61.8 mg, 0.130 mmol) and potassium phosphate (881 mg, 4.15 mmol) was degassed under ultrasonic irradiation, and stirred at 100° C. for 16 hours under a nitrogen atmosphere. After the reaction mixture was cooled to room temperature, 6M hydrochloric acid (2 ml) and water (15 ml) were added, followed by stirring at room temperature for 1 hour. The precipitated solid was filtered, and ethyl acetate (10 ml) was added, followed by irradiation of ultrasonic wave. The solid was filtered, and washed with ethyl acetate, whereby 4-(4-{2-[bis-(4-methoxy-benzyl)-amino]-pyrimidin-5-yl}-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl)-benzoic acid was obtained as a yellow solid (855 mg, 100%).

Provenance & Evidence