Phenyl isocyanate → HCID 67386598, compound

Participants

Reaction Steps

Using bis-(4-methoxy-benzyl)-[5-(2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-pyrimidin-2-yl]-amine (50 mg) and phenylisocyanate (30 μl) instead of ethylisocyanate, in the same manner as Example 1-D-03, a crude product of 4-{2-[bis-(4-methoxy-benzyl)-amino]-pyrimidin-5-yl}-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidine-7-carboxylic acid phenylamide was obtained, and then the PMB groups were removed according to Deprotection method 1′, to obtain the desired compound (D-28) as a yellow solid (4.2 mg, 25%).

Provenance & Evidence