Ethyl 3-isocyanatopropanoate → 3-[(4-{2-[Bis-(4-methoxy-benzyl)-amino]-pyrimidin-5-yl}-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidine-7-carbonyl)-amino]-propionic acid ethyl ester

Participants

Reaction Steps

Using bis-(4-methoxy-benzyl)-[5-(2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-pyrimidin-2-yl]-amine (100 mg) and 3-isocyanato-propionic acid ethyl ester (244 μl) instead of isocyanato-acetic acid ethyl ester, in the same manner as Example 1-D-29 in Step A, a crude product of the desired compound was obtained (114 mg, quant.).

Provenance & Evidence