Ammonium Chloride → HCID 86640122, compound

Participants

Reaction Conditions

Reaction Steps

To a DMF solution (1 ml) of [(4-{2-[bis-(4-methoxy-benzyl)-amino]-pyrimidin-5-yl}-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidine-7-carbonyl)-amino]-acetic acid (30 mg) obtained in Step A, ammonium chloride (5.0 mg), N-ethyldiisopropylamine (41 μl), HOBt (6.3 mg) and WSCI (13.4 mg) was added, followed by stirring at 80° C. for 3 hours. To this, water was added, and the resulting solid was filtered, to obtain a crude product of the desired compound (27 mg, 91%).

Provenance & Evidence